Chitin-fibroin-hydroxyapatite membrane for guided bone regeneration: micro-computed tomography evaluation in a rat model
백영재, 김중한, 송재민, 윤상용, 김홍성, 신상훈,
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백영재 ( Baek Young-Jae ) - Pusan National University School of Dentistry Department of Oral and Maxillofacial Surgery
김중한 ( Kim Jung-Han ) - Pusan National University School of Dentistry Department of Oral and Maxillofacial Surgery
송재민 ( Song Jae-Min ) - Pusan National University School of Dentistry Department of Oral and Maxillofacial Surgery
윤상용 ( Yoon Sang-Yong ) - Good Gang-An Hospital Department of Oral and Maxillofacial Surgery
김홍성 ( Kim Hong-Sung ) - Pusan National University College of Natural Resources and Life Science Department of Biomaterials Science
신상훈 ( Shin Sang-Hun ) - Pusan National University School of Dentistry Department of Oral and Maxillofacial Surgery
Abstract
Background: In guided bone regeneration (GBR) technique, many materials have been used for improving biological effectiveness by adding on membranes. The new membrane which was constructed with chitin-fibroin-hydroxyapatite (CNF/HAP) was compared with a collagen membrane (Bio-Gide®) by means of micro-computed tomography.
Methods: Fifty-four rats were used in this study. A critical-sized (8 mm) bony defect was created in the calvaria with a trephine bur. The CNF/HAP membrane was prepared by thermally induced phase separation. In the experimental group (n?=?18), the CNF/HAP membrane was used to cover the bony defect, and in the control group (n?=?18), a resorbable collagen membrane (Bio-Gide®) was used. In the negative control group (n?=?18), no membrane was used. In each group, six animals were euthanized at 2, 4, and 8 weeks after surgery. The specimens were analyzed using micro-CT.
Results: Bone volume (BV) and bone mineral density (BMD) of the new bone showed significant difference between the negative control group and membrane groups (P?
Conclusions: The CNF/HAP membrane has significant effect on the new bone formation and has the potential to be applied for guided bone regeneration.
키워드
Chitin-fibroin-hydroxyapatite; Guided bone regeneration; Micro-computed tomography; Rat calvarial defect
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